Misoprostol is given orally for the purpose of an abortion. It is used in the first few weeks of pregnancy along with mifepristone to induce a miscarriage.
It is a synthetic 19-nonsteroidal which is related to norethindrone. It binds to the intercellular progesterone receptor where it competitively inhibits progesterone attachment and thus the effects of endogenous progesterone.
Uses of mifepristone
- Termination of early pregnancy in combination with prostaglandins.
- Termination of pregnancy during trimester 2 and 3.
- Induction of labor in the case of fetus mortals.
- Immediate postcoital emergency contraception.
- Progesterone dependent malignancies.
- breast cancer.
- meningioma.
- endometriosis.
- uterine leiomyoma.
- induction of normal labor.
- extrauterine pregnancy.
- induction of menses.
- Immediate post-coital emergency contraception.
- Contraception with continuous/intermittent administration.
- Progesterone dependent malignancies, breast cancer, meningioma.
- Endometriosis, uterine leiomyoma induction of normal labor.
- Extrauterine pregnancy.
- Induction of menses.
Dosage
For termination of pregnancy (49 days or less duration) Oral: 600 mg (three pills200 mg) of Misoprostol as a single oral dose followed by two days(48 hours) 400 mcg (two tablets of 200 mcg ) of misoprostol as a single dose.For cervical ripening: preoperative treatment with mifepristone 50-600 mg, 24-30 h before surgery.
Post-coital contraception: Oral: a single dose of 600 mg within 72 hours of unprotected intercourse.
Contraceptive: 2-5 mg per day for 30 days inhibits ovulation and delays menstruation.
Once a month contraceptive pill: oral: a single dose of 200 mg taken the second day after the mid-cycle.
the side effect of mifepristone
- Excessive vaginal bleeding.
- Tiredness.
- Weakness.
- Uterine cramping.
- Back pain.
- Diarrhea.
- Dizziness.
- Headache.
- Nausea.
- Vomiting.
- Dyspepsia.
- Anxiety.
- Belching.
- Cough.
- Fever.
- Flu-like symptoms.
- Heartburn.
- Increased clear or white vaginal discharge.
- Itching of the vagina or genital area.
- Fatigue.
- Pain during sexual intercourse.
- Pain or tenderness around eyes and cheekbones.
- Pale skin.
- Shortness of breath.
- Insomnia.
- The tightness of the chest or wheezing unusual bleeding or bruising sinusitis uterine hemorrhage, vaginitis.
Special precautions
In some cases, excessive bleeding may occur. Treatment may be required in that case. Women with heart, liver, renal, hypertension require caution. Women above 35 years of age and smokers should use caution.also read
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