uses of Iron in the body

The drugs that increase the formation of RBCs (Hb)  are called haematinics. they are iron, folic acid, vitamin B12, ferrous sulfate.

Iron :

Iron present in the blood as a component of hemoglobin. It is an essential component of blood production. Iron is necessary for the normal growth of the body.

More iron is required to maintain hemoglobin due to higher physical demand during pregnancy, breastfeeding, or infancy.

The daily requirement of iron for an adult is 1 - 1.5 mg/day. Whereas iron requirements are more in women.

In the iron deficiency state, the amount of iron present in the body decreases, due to which the level of hemoglobin decreases. Which is gradually completed by taking extra iron. Iron content refills very slowly, even after hemoglobin is normal. Therefore, the normalization of HB oral iron therapy continues for a long time.

Use of iron - iron deficiency and bleeding conditions.

Loss due to iron deficiency

  • poor well-being,
  • early fatigue,
  • vertigo,
  • palpitation,
  • neuropathic symptoms' cloudiness of intellectual process,
  • breathlessness,
  • body aches,
  • vague muscle,
  • iron-deficiency anemia.

Dosage of iron:

Ferrous sulfate - 200- 600 mg daily.

Ferrous gluconate - 300- 1200 mg daily.

Preparation of iron:

  1.  ferrous sulphate dried -  200- 300 mg daily,
  2. ferrous gluconate - 1.2- 1.8 gm in divided dose daily,
  3. ferrous fumarate - 200- 400 mg in divided dose,
  4. ferrous succinate - 200- 400 mg in the divided daily dose,
  5. colloidal iron - 200- 400 mg daily,
  6. ferrous ammonium citrate - 200- 400 mg daily,
  7. sodium iron edetate - 150 mg daily,
  8. iron dextran injection (50 mg) - 1 ml by I M,
  9. iron sorbitol injection (50 mg/ml) - 1.5 mg/ kg IM.

Precaution for uses:

history of peptic ulcer, severe renal failure.

Side effects of iron:

  • gastritis,
  • constipation/ diarrhoea,
  • change the color of stool to black,
  • abdominal discomfort,
  • pain.
  • Nausea.

iron intoxication:

ingestion of more than 50 gm of iron. results in Iron poisoning.

Sign of iron poisoning:

  • abdominal pain,
  • vomiting,
  • acidosis,
  • cardiovascular collapse,
  • coma and death.

Management of Iron poisoning:

  • Gastric lavage,
  • IV administration desferrioxamine (antidote)
  • Fluid and electrolyte replacement.

Folic acid:

folic acid uses to make new cells. Folic acid is essential for the normal growth of the body, but it is more necessary for pregnant women. 

Folic acid help prevents major birth defects of the brain and spine of the baby. These birth defects are neural tube defects or NTDs. A pregnant woman needs to take folic acid every day.

folate-deficient megaloblastic anemia - Dosage - 5 mg daily for 4 months.

Prophylaxis of megaloblastic anemia in pregnancy - Dosage - o.2 - 0.5 mg daily.

prophylaxis of neural tube defect in pregnancy -  Dosage - 4 or 5 mg daily starting before pregnancy & continued through the 1st trimester.

as a supplement for women of childbearing potential. - Dosage - 0.4 mg daily.

Vitamin B12:

Vitamin B12 also called cobalamin, vitamin B12 plays an important role in nerve tissue health, brain function, and red blood formation. megaloblastic anemia is caused by vitamin B12 deficiency.

Dosage - adult - 500 mcg daily IM/IV 3 time/week.