Adrenaline given by doctor in an emergency, know how it works

Adrenaline belongs to the sympathomimetics class of drugs. primarily given for the treatment of cardiac arrest, hypotension due to shock, and life-threatening allergic reactions. 

Adrenaline should be taken as advised by a doctor. It is available in the form of injection. Adrenaline is also known as epinephrine. It is a life-saving drug.  Adrenaline is widely used in abnormal heart function, blood pressure, and eye preparations. It is used for, cardiac arrest. hypotension due to shock, and life-threatening allergic reactions.

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Effects of adrenaline or epinephrine 

On the heart

Adrenaline increases heart rate, the force of contraction, and cardiac output. Adrenaline increases blood pressure, due to its direct effect on the heart and vasoconstriction of blood vessels. 

Due to its direct effect on the heart and vasoconstriction of blood vessels, adrenaline relaxes the bronchial smooth muscles and produces bronchodilation. Adrenaline reduces GIT motility

On Eyes

Adrenaline produces dilation of pupils i. e, mydriasis

Side effects of adrenaline

  • Severe hypertension
  • Palpitation
  • Cardiac arrhythmia
  • Acute pulmonary edema
  • Fear, 
  • Anxiety 
  • Restlessness
  • Headaches, 
  • Tremors.

Uses of adrenaline 

  • Adnerline uses in bronchial asthma
  • Allergy reaction
  •  Cardiac arrest
  • Control the hemorrhage
  • Added with local anesthetic drugs.

Should not treat by adrenalin Contraindications

  • Hypertension
  • Thyrotoxicosis
  • Arteriosclerosis
  • Spinal anesthesia.

What is dale vasomotor reversal?

Adrenaline îs a mixed agonist that produces an increase in systolic but decreases in diastolic blood pressure.

A secondary fall occurs when the concentration of adrenaline decreases.

The drugs like ergotoxine reverse the actions of adrenaline which is called " Dale's vasomotor reversal"

the vasoconstrictor action of adrenaline is blocked by ergot alkaloid. this may lead to stimulation of both

receptors by adrenaline and thus causing a fall in blood pressure.

The high dose of adrenaline with ergot extract also blocks the effects of adrenaline.

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