1978 a woman died of rabies due to a cornea transplant from an infected person.
In 1978, there was a case where a woman in the United States died of rabies after receiving a cornea transplant from a donor who was infected with the virus. This was one of the first documented cases of rabies transmission through organ transplantation.
The woman received the cornea transplant as part of a routine eye surgery, and the donor's rabies infection was not detected at the time of the transplant. Several weeks after the surgery, the woman began to experience symptoms of rabies, and unfortunately, she ultimately died from the disease.
This case led to significant changes in the screening process for organ donors, as well as increased awareness of the risk of rabies transmission through transplantation. Today, rigorous screening measures are in place to ensure that organs are safe for transplantation, and the risk of rabies transmission through organ donation is very low.
The rabies viruses
The rabies virus is a highly infectious and potentially deadly virus that belongs to the family Rhabdoviridae and belongs to the lyssaviruses species. This disease is zoonotic. Means disease caused from one species to another. Like, dogs, cats, horses, and mice and bats, etc., in humans. The virus is bullet-shaped and has a single strand of RNA as its genetic material. It is highly neurotropic, meaning it has a strong affinity for nerve cells and can easily invade and replicate within them. After an animal or person is infected with the rabies virus, it may take several weeks or even months for symptoms to appear. The rabies virus affects the central nervous system and the brain. As a result, man acts like an animal, is afraid of water, and is afraid of wind. react like a dog. In the end death, within 7 to 14 of the occurring of symptoms.
The rabies virus travels through the peripheral nerves to the brain. The incubation period of the disease is typically a few days to a few months in humans, depending on the site and severity of exposure, the distance the virus must travel to reach the central nervous system.
The initial symptoms of rabies are headache, fever, sore throat, pain during swallowing anything solid. But later the person suffering from rabies goes through a lot of trouble. His behavior becomes unusual and aggressive. Due to paralytic effects in the pharyngeal muscle, eating is not possible. The patient runs away from water. Saliva keeps dripping from the mouth.
The patient swallows nothing due to the paralytic effect in the pharyngeal muscle. Malnutrition occurs. Gradually paralysis spreads throughout the body. In the final stages of the disease, the infected person or animal may experience paralysis, respiratory failure, and eventually death.
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